SV2B rabbit pAb

This gene encodes a member of the synaptic vesicle proteins 2 (SV2) family and major facilitator superfamily of proteins. This protein and other members of the family are localized to synaptic vesicles and may function in the regulation of vesicle trafficking and exocytosis. Studies in mice suggest that the encoded protein may act as a protein receptor for botulinum neurotoxin E in neurons, and that this protein may be important for the integrity of the glomerular filtration barrier. This gene shows reduced expression in areas of synaptic loss in the hippocampus of human temporal lobe epilepsy patients. [provided by RefSeq, Sep 2016],

Product Specifications

Background

UniProt

Q7L1I2

Swiss Prot

Q7L1I2

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein.AA range 1-50

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

75kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

75kD

Fragment

IgG

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, acrosome . Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity) . Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity) . .