SNX5 rabbit pAb

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013],

Product Specifications

Background

UniProt

Q9Y5X3

Swiss Prot

Q9Y5X3

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

SNX5

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

44kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

44kD

Fragment

IgG

Subcellular Location

Endosome . Early endosome . Early endosome membrane ; Peripheral membrane protein; Cytoplasmic side. Cell membrane ; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns (3,4) P2) (PubMed:15561769) . Detected on macropinosomes (PubMed:16968745, PubMed:21048941) . Targeted to membrane ruffles in response to EGFR stimulation. .