SRPK2 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by phosphorylation on Ser-52 and Ser-588. function: Phosphorylates RS domain-containing proteins, such as SFRS1 and SFRS2 on serine residues. Role in spliceosome assembly and in mediating the trafficking of splicing factors. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. sequence Caution: The cDNA appears to contain a duplicated region. similarity: Belongs to the protein kinase superfamily. similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. similarity: Contains 1 protein kinase domain. tissue specificity: Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.

Product Specifications

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Ser-52 and Ser-588., function:Phosphorylates RS domain-containing proteins, such as SFRS1 and SFRS2 on serine residues. Role in spliceosome assembly and in mediating the trafficking of splicing factors. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids., sequence caution:The cDNA appears to contain a duplicated region., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family., similarity:Contains 1 protein kinase domain., tissue specificity:Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.

UniProt

P78362

Swiss Prot

P78362

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

75kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

75kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus, nucleoplasm . Nucleus speckle . Chromosome . Shuttles between the nucleus and the cytoplasm (PubMed:19592491, PubMed:21157427, PubMed:21056976) . KAT5/TIP60 inhibits its nuclear translocation (PubMed:21157427) . Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (PubMed:19592491) . Preferentially localizes across the entire gene coding region (PubMed:28076779) . During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorlyated POLR2A/RNA polymerase II and helicase DDX23 (PubMed:28076779) . .