NEK1 rabbit pAb

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010],

Product Specifications

Background

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD) . Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

UniProt

Q96PY6

Swiss Prot

Q96PY6

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 280-360

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

138kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

138kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Associated with the pericentriolar material (PubMed:21211617) . Localizes to centrosome during interphase and mitosis (By similarity) . Translocated from cytoplasm to discrete nuclear foci at sites of DNA damage (PubMed:15604234) . .