RFIP5 rabbit pAb

Disease: Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE). Domain: Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg (2+) rather than Ca (2+). function: Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. PTM: Phosphorylated on serine and threonine residues. similarity: Contains 1 C2 domain. subunit: Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding. tissue specificity: Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.

Product Specifications

Background

Disease:Antibodies against RIP11 are found in sera from patients with systemic lupus erythematosus (SLE) or Sjoegren syndrome (SS), and in the sera from mothers of children with neonatal lupus erythematosus (NLE) ., domain:Binds to vesicles enriched in neutral phospholipids via its C2 domain. The interaction is favored by Mg (2+) rather than Ca (2+) ., function:Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane., PTM:Phosphorylated on serine and threonine residues., similarity:Contains 1 C2 domain., subunit:Forms an heterooligomeric complex with RAB11FIP4. Binds NAPG and SSA2. Binds RAB11A that has been activated by GTP binding., tissue specificity:Detected at low levels in heart, brain, placenta, lung, liver, adipocytes, kidney, spleen, skeletal muscle and pancreas.

UniProt

Q9BXF6

Swiss Prot

Q9BXF6

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 570-650

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

71kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

71kD

Fragment

IgG

Subcellular Location

Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Peripheral membrane protein . Mitochondrion membrane; Peripheral membrane protein.