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PPR1A rabbit pAb

Function: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. PTM: Phosphorylation of Thr-35 is required for activity. similarity: Belongs to the protein phosphatase inhibitor 1 family. subunit: Interacts with PPP1R15A.

Product Specifications

Background

Function:Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B) . Does not inhibit type-2 phosphatases., PTM:Phosphorylation of Thr-35 is required for activity., similarity:Belongs to the protein phosphatase inhibitor 1 family., subunit:Interacts with PPP1R15A.

Gene ID

5502

UniProt

Q13522

Cellular Locus

Extracellular space,cytoplasm,

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human protein . at AA range: 40-120

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, ELISA

Validated Applications

WB,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

18kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES10055-1.pdf

Observed Molecular Weight

18 kD

Subcellular Location

Extracellular space, cytoplasm

Gene ID (Human)

5502

SwissProt (Human)

Q13522

Available Sizes

Curated Selection

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