PR40A rabbit pAb
Domain: The WW domains are essential for localization to nuclear speckles. function: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). May be involved in pre-mRNA splicing. sequence Caution: Contaminating sequence. Potential poly-A sequence starting in position 409. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the PRPF40 family. similarity: Contains 2 WW domains. similarity: Contains 5 FF domains. subunit: Interacts with the N-terminus of HTT. Interacts with the phosphorylated carboxyterminal domain of POLR2A. Interacts with SF1, SRPK1 CARD8, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP. tissue specificity: Widely expressed.
Product Specifications
Background
Gene ID
55660
UniProt
O75400
Cellular Locus
Nucleus speckle. Nucleus matrix. Colocalizes with AKAP8L in the nuclear matrix..
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 450-530
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
105kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES10043-1.pdf
Observed Molecular Weight
105 kD
Subcellular Location
Nucleus speckle . Nucleus matrix . Colocalizes with AKAP8L in the nuclear matrix. .
Gene ID (Human)
55660
SwissProt (Human)
O75400
Available Sizes
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