PHC3 rabbit pAb
Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 FCS-type zinc finger. similarity: Contains 1 SAM (sterile alpha motif) domain. subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2.
Product Specifications
Background
Gene ID
80012
UniProt
Q8NDX5
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 720-800
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
108kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES10019-1.pdf
Observed Molecular Weight
108 kD
Subcellular Location
Nucleus .
Gene ID (Human)
80012
SwissProt (Human)
Q8NDX5
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ABCA10 CRISPR Knock Out 293T Cell Line (Human)
Recombinant Mouse Keratin, type II cytoskeletal 71 (Krt71)
Recombinant Mouse Keratin, type II cytoskeletal 71 (Krt71)