PHC3 rabbit pAb
Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 FCS-type zinc finger. similarity: Contains 1 SAM (sterile alpha motif) domain. subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2.
Product Specifications
Background
UniProt
Q8NDX5
Swiss Prot
Q8NDX5
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 720-800
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
108kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
108kD
Fragment
IgG
Subcellular Location
Nucleus .
Gene ID (Human)
80012
Available Sizes
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