PAR6G rabbit pAb

Domain: The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases. function: Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. similarity: Belongs to the PAR6 family. similarity: Contains 1 OPR domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 pseudo-CRIB domain. subunit: Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ. tissue specificity: Widely expressed, with a higher expression in fetal and adult kidney.