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GNA13 rabbit pAb

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. PTM: Palmitoylation is critical for proper membrane localization and signaling. PTM: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. similarity: Belongs to the G-alpha family. G (12) subfamily. subcellular location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.

Product Specifications

Background

Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., PTM:Palmitoylation is critical for proper membrane localization and signaling., PTM:Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation., similarity:Belongs to the G-alpha family. G (12) subfamily., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.

Gene ID

10672

UniProt

Q14344

Cellular Locus

Cell membrane ; Lipid-anchor. Melanosome. Cytoplasm. Nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424). In round spermatids, also present in the nuclei (PubMed:18703424)..

Host

Rabbit

Species Reactivity

Human,Mouse

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, ELISA

Validated Applications

WB,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

41kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES9699-1.pdf

Observed Molecular Weight

41 kD

Subcellular Location

Cell membrane ; Lipid-anchor . Melanosome . Cytoplasm . Nucleus . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424) . In round spermatids, also present in the nuclei (PubMed:18703424) . .

Gene ID (Human)

10672

SwissProt (Human)

Q14344

Available Sizes

Curated Selection

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