GNA13 rabbit pAb

Function: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. PTM: Palmitoylation is critical for proper membrane localization and signaling. PTM: Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation. similarity: Belongs to the G-alpha family. G (12) subfamily. subcellular location: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. subunit: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.

Product Specifications

Background

Function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems., PTM:Palmitoylation is critical for proper membrane localization and signaling., PTM:Phosphorylation on Thr-203 by PKA destabilizes the heterotrimer of alpha, beta and gamma, and inhibits Rho activation., similarity:Belongs to the G-alpha family. G (12) subfamily., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with UBXD5.

UniProt

Q14344

Swiss Prot

Q14344

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Target

GNA13

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

41kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

41kD

Fragment

IgG

Subcellular Location

Cell membrane ; Lipid-anchor . Melanosome . Cytoplasm . Nucleus . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) . Detected in the cytoplasm of Leydig cells and in the seminiferous epithelium, including differentiating cells from the spermatogonia to mature spermatozoa stages (PubMed:18703424) . In round spermatids, also present in the nuclei (PubMed:18703424) . .