PA24F rabbit pAb

Catalytic activity: Phosphatidylcholine + H (2)O = 1-acylglycerophosphocholine + a carboxylate. Domain: The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca (2+). enzyme regulation: Stimulated by cytosolic Ca (2+). function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine. similarity: Contains 1 C2 domain. similarity: Contains 1 PLA2c domain. subcellular location: Translocates to lysosomal membranes in a calcium-dependent fashion.