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PDE1A rabbit pAb

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca (2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca (2+) (Michibata et al. 2001 [PubMed 11342109]; Fidock et al. 2002 [PubMed 11747989]). [supplied by OMIM, Oct 2009],

Product Specifications

Background

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca (2+) /calmodulin (see CALM1; MIM 114180) -dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca (2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]) .[supplied by OMIM, Oct 2009]

UniProt

P54750

Swiss Prot

P54750

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

58kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

58kD

Fragment

IgG

Subcellular Location

Nucleus, cytosol, neuronal cell body

Gene ID (Human)

5136

Available Sizes

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