Histone H3K9me3 (1-15)

Histone H3K9me3 (1-15) (H3 (1-15) K9me3) is a histone posttranslational modification (PTM) that has emerged as hallmark of pericentromeric heterochromatin. Trimethylation of histone H3 at lysine 9 is associated with gene repression, prevents transcription factor binding[1][2].

Product Specifications

CAS Number

[951011-30-6]

Product Name Alternative

H3 (1-15) K9me3

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/histone-h3k9me3-1-15.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCC[N+](C)(C)C)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(NCC(NCC(N[C@@H](CCCCN)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C66H124N25O21+

Molecular Weight

1603.85

References & Citations

[1]Woon EC, et al. Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. Angew Chem Int Ed Engl. 2012 Feb 13;51 (7) :1631-4.|[2]Mosch K, et al. HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. PLoS One. 2011 Jan 18;6 (1) :e15894.