DVD-445
DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].
Product Specifications
CAS Number
[2375846-41-4]
UNSPSC
12352005
Target
TrxR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dvd-445.html
Concentration
10mM
Purity
98.36
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OCCN(C(C1=CC=C(F)C=C1)C(NC(C)(C)C)=O)C)/C=C/C(C2=CC=C(F)C=C2)=O
Molecular Formula
C25H28F2N2O4
Molecular Weight
458.50
References & Citations
[1]Jovanović M, et al. Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy. Eur J Med Chem. 2019 Aug 1;181:111580.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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