IF2B1 rabbit pAb

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, P-body . Cytoplasm, Stress granule . Cell projection, lamellipodium. Cell projection, dendrite . Cell projection, dendritic spine . Cell projection, growth cone. Cell projection, filopodium . Cell projection, axon . In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription (By similarity) . In the cytoplasm, localizes in cytoplasmic mRNP granules. Colocalizes with microtubules in growth cone filopodia and along neurites in neuronal cells (By similarity) . Cytoplasmic colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is los