HJURP rabbit pAb

Function: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Directly binds Holliday junctions. sequence Caution: Translated as Arg. subcellular location: Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage. subunit: Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3. 1- or H3. 3-containing nucleosomes. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN. tissue specificity: According to PubMed: 17256767 highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed: 17823411 highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.