DYRK3 rabbit pAb

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Nucleus . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with membraneless organelles in the cytoplasm and nucleus (PubMed:29973724) . Shuttles between cytoplasm and stress granules (PubMed:20167603) . Localized predominantly on distinct speckles distributed throughout the cytoplasm of the cell (PubMed:20167603) . At low concentration, showns a homogeneous distribution throughout the cytoplasm and does not condense in speckles. During oxidative and osmotic stress, localizes to stress granules (PubMed:20167603) . .