ATP synthase inhibitor 3
Product Specifications
UNSPSC Description
ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC50=0.788 μM). ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC50 value of 30μM[1].
Target Antigen
ATP Synthase; Bacterial
Type
Reference compound
Related Pathways
Anti-infection;Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/atp-synthase-inhibitor-3.html
Smiles
O=C(CN1CCC(N2C(C=CC(Cl)=C3)=C3N(CC4=CC=C(F)C=C4)C2=O)CC1)N5C6=CC=CC=C6SC7=C5C=CC=C7
Molecular Weight
599.12
References & Citations
[1]Reddyrajula, et al. "N-Acyl phenothiazines as mycobacterial ATP synthase inhibitors: Rational design, synthesis and in vitro evaluation against drug sensitive, RR and MDR-TB." Bioorganic Chemistry (2024): 107702.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162804/ATP-synthase-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162804/
Clinical Information
No Development Reported
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