ATP synthase inhibitor 3

ATP synthase inhibitor 3 (compound PT6) is an orally active inhibitor of mycobacterial F-ATP synthase (IC50=0.788 μM) . ATP synthase inhibitor 3 inhibits the growth of Mycobacterium tuberculosis H37Rv strain (ATCC-27294) in vitro and depletes intracellular ATP levels at an IC50 value of 30μM[1].

Product Specifications

UNSPSC

12352101

Target

ATP Synthase; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/atp-synthase-inhibitor-3.html

Smiles

O=C(CN1CCC(N2C(C=CC(Cl)=C3)=C3N(CC4=CC=C(F)C=C4)C2=O)CC1)N5C6=CC=CC=C6SC7=C5C=CC=C7

Molecular Formula

C33H28ClFN4O2S

Molecular Weight

599.12

References & Citations

[1]Reddyrajula, et al. "N-Acyl phenothiazines as mycobacterial ATP synthase inhibitors: Rational design, synthesis and in vitro evaluation against drug sensitive, RR and MDR-TB." Bioorganic Chemistry (2024) : 107702.