PEK/PERK rabbit pAb
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015],
Product Specifications
Background
Product Name Alternative
UniProt
Q9NZJ5
Swiss Prot
Q9NZJ5
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PEK/PERK Polyclonal
Target
PERK
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Other Product Names
Gene ID (Human)
9451
Available Sizes
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