Thioredoxin rabbit pAb

The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Product Specifications

Background

Product Name Alternative

Thioredoxin (Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP)

UniProt

P10599

Swiss Prot

P10599

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human Thioredoxin. at AA range: 52-101

Target

Thioredoxin

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

Buffer

-20°C/1 year

Molecular Weight

12kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

12kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Secreted . Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029) . Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054) . Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054) . Secreted by a leaderless secretory pathway (PubMed:1332947) . .