GLI-1 rabbit pAb

This gene encodes a member of the Kruppel family of Zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],

Product Specifications

Background

This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

UniProt

P08151

Swiss Prot

P08151

Reactivity

Human; Mouse

Immunogen

Synthesized peptide derived from human GLI-1. at AA range: 460-490

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000, ELISA 1:10000-20000

Molecular Weight

120kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

120kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Tethered in the cytoplasm by binding to SUFU (PubMed:10806483) . Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483) . Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745) . Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441) . .; [Isoform 2]: Cytoplasm . Nucleus .