FAS-L rabbit pAb

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014],

Product Specifications

Background

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE) . Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]

UniProt

P48023

Swiss Prot

P48023

Reactivity

Human; Rat; Mouse

Immunogen

Synthetic peptide from human protein at AA range: 121-170

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, ELISA 1:10000-20000

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cell membrane ; Single-pass type II membrane protein . Cytoplasmic vesicle lumen . Lysosome lumen . Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290) . Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115) . .; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted . May be released into the extracellular fluid by cleavage from the cell surface. .; [FasL intracellular domain]: Nucleus . The FasL ICD cytoplasmic form is translocated into the nucleus. .

Other Product Names

Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand; APTL; CD95 ligand; CD95-L; Fas antigen ligand; Fas ligand; FasL; CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain; Soluble Fas ligand; sFasL) ; ADAM10-processed FasL form (APL) ; FasL intracellular domain (FasL ICD; SPPL2A-processed FasL form; SPA) ]