HLA-DMβ rabbit pAb
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB;Really interesting new gene 7 protein)
Gene ID
3109
UniProt
P28068
Cellular Locus
Host
Rabbit
Species Reactivity
Human
Reactivity
Human
Immunogen
Synthetic peptide from human protein at AA range: 40-100
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, ELISA
Validated Applications
IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8783-1.pdf
Subcellular Location
Other Product Names
HLA class II histocompatibility antigen, DM beta chain (MHC class II antigen DMB; Really interesting new gene 7 protein)
Gene ID (Human)
3109
SwissProt (Human)
P28068
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
