DC-LAMP rabbit pAb

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al. 1998 [PubMed 9768752]). [supplied by OMIM, Dec 2010],

Product Specifications

Background

Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]) .[supplied by OMIM, Dec 2010]

UniProt

Q9UQV4

Swiss Prot

Q9UQV4

Reactivity

Human; Rat; Mouse

Immunogen

Synthetic peptide from human protein at AA range: 261-310

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000, IHC-p 1:500-200, ELISA 1:10000-20000

Molecular Weight

44kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

44kD

Fragment

IgG

Subcellular Location

Cell surface . Lysosome membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752) . Detected on lysosomes in mature dendritic cells (PubMed:9768752) . .

Other Product Names

Lysosome-associated membrane glycoprotein 3 (LAMP-3; Lysosomal-associated membrane protein 3; DC-lysosome-associated membrane glycoprotein; DC LAMP; Protein TSC403; CD antigen CD208)