CIS rabbit pAb
Cytokine inducible SH2 containing protein (CISH) Homo sapiens The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of Cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of Cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Product Specifications
Background
Synonyms
Cytokine-inducible SH2-containing protein (CIS;CIS-1;Protein G18;Suppressor of cytokine signaling;SOCS)
Gene ID
1154
UniProt
Q9NSE2
Cellular Locus
Cytoplasm,cytosol,plasma membrane,
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 30-90
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, ELISA
Validated Applications
IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8670-1.pdf
Subcellular Location
Cytoplasm, cytosol, plasma membrane
Other Product Names
Cytokine-inducible SH2-containing protein (CIS; CIS-1; Protein G18; Suppressor of cytokine signaling; SOCS)
Gene ID (Human)
1154
SwissProt (Human)
Q9NSE2
Available Sizes
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