GRP78 BiP rabbit pAb
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell. [provided by RefSeq, Sep 2010],
Product Specifications
Background
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]
Product Name Alternative
78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)
UniProt
P11021
Swiss Prot
P11021
Reactivity
Human; Mouse; Rat; Fish
Immunogen
Synthetic peptide from human protein at AA range: 505-570
Target
HSP A5/GRP78
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000.IHC-p/f:1:50-300. ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
78kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
78kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum lumen . Melanosome . Cytoplasm . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545) . Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390) . .
Other Product Names
78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)
Gene ID (Human)
3309
Available Sizes
Curated Selection
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