GRP78 BiP rabbit pAb

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell. [provided by RefSeq, Sep 2010],

Product Specifications

Background

Product Name Alternative

78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)

UniProt

P11021

Swiss Prot

P11021

Reactivity

Human; Mouse; Rat; Fish

Immunogen

Synthetic peptide from human protein at AA range: 505-570

Target

HSP A5/GRP78

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000.IHC-p/f:1:50-300. ELISA 1:10000-20000

Buffer

-20°C/1 year

Molecular Weight

78kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

78kD

Fragment

IgG

Subcellular Location

Endoplasmic reticulum lumen . Melanosome . Cytoplasm . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545) . Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390) . .

Other Product Names

78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)