COL17A1 rabbit pAb

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Product Name Alternative

COL17A1 BP180 BPAG2

UniProt

Q9UMD9

Swiss Prot

Q9UMD9

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human COL17A1. AA range:481-530

Target

COL17A1

Clonality

Polyclonal

Source

Rabbit

Applications

WB IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

150kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

150kD

Fragment

IgG

Subcellular Location

Cell junction, hemidesmosome. Membrane; Single-pass type II membrane protein. Localized along the plasma membrane of the hemidesmosome.; [120 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Exclusively localized to anchoring filaments. Localized to the epidermal side of split skin.; [97 kDa linear IgA disease antigen]: Secreted, extracellular space, extracellular matrix, basement membrane. Localized in the lamina lucida beneath the hemidesmosomes.