COL25A1 rabbit pAb
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Product Specifications
Background
UniProt
Q9BXS0
Swiss Prot
Q9BXS0
Reactivity
Human; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 101-150
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Molecular Weight
64kD
Storage Conditions
-20°C/1 year
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8542-1.pdf
Observed Molecular Weight
64kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
Other Product Names
COL25A1
Gene ID (Human)
84570
Available Sizes
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