RCC1 rabbit pAb
Disease: Patients with Raynaud disease produce antibodies that bind to RCC1. function: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. similarity: Contains 7 RCC1 repeats. subcellular location: Becomes dispersed throughout the cytoplasm during mitosis.
Product Specifications
Background
Disease:Patients with Raynaud disease produce antibodies that bind to RCC1., function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA., similarity:Contains 7 RCC1 repeats., subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.
UniProt
P18754
Swiss Prot
P18754
Reactivity
Human; Mouse; Rat
Immunogen
Synthetic peptide from human protein at AA range: 301-350
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000
Molecular Weight
45kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
45kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828) . Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449) . .
Other Product Names
RCC1 CHC1
Gene ID (Human)
1104
Available Sizes
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