RCC1 rabbit pAb

Disease: Patients with Raynaud disease produce antibodies that bind to RCC1. function: Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. similarity: Contains 7 RCC1 repeats. subcellular location: Becomes dispersed throughout the cytoplasm during mitosis.

Product Specifications

Background

Disease:Patients with Raynaud disease produce antibodies that bind to RCC1., function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA., similarity:Contains 7 RCC1 repeats., subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.

UniProt

P18754

Swiss Prot

P18754

Reactivity

Human; Mouse; Rat

Immunogen

Synthetic peptide from human protein at AA range: 301-350

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000

Molecular Weight

45kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

45kD

Fragment

IgG

Subcellular Location

Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828) . Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449) . .