AMBRA1 rabbit pAb

Function: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. similarity: Contains 3 WD repeats. subunit: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

Product Specifications

Background

Function:Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation., similarity:Contains 3 WD repeats., subunit:Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.

Product Name Alternative

Autophagy/beclin-1 regulator 1

UniProt

Q9C0C7

Swiss Prot

Q9C0C7

Reactivity

Human; Mouse

Immunogen

Synthetic Peptide of AMBRA1

Target

AMBRA1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000, ELISA 1:10000-20000

Buffer

-20°C/1 year

Molecular Weight

140kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

140kD

Fragment

IgG

Subcellular Location

Endoplasmic reticulum . Cytoplasm, cytoskeleton . Cytoplasmic vesicle, autophagosome . Mitochondrion . Cytoplasm, cytosol . Nucleus . Cell junction, focal adhesion . Localizes to the cytoskeleton in absence of autophagy induction (PubMed:20921139) . Upon autophagy induction, AMBRA1 relocalizes to the endoplasmic reticulum to enable autophagosome nucleation (PubMed:20921139) . Partially localizes at mitochondria in normal conditions (PubMed:21358617) . Localizes also to discrete punctae along the ciliary axoneme (By similarity) . .