PI 3 Kinase Class 3 rabbit pAb

Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. Cofactor: Manganese. function: Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes. similarity: Belongs to the PI3/PI4-kinase family. similarity: Contains 1 PI3K/PI4K domain. subunit: Probably forms a complex with AMBRA1 and BECN1 (By similarity). Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. tissue specificity: Ubiquitously expressed, with a highest expression in skeletal muscle.

Product Specifications

Background

Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate., cofactor:Manganese., function:Catalytic subunit of the PI3K complex. Involved in the transport of lysosomal enzyme precursors to lysosomes., similarity:Belongs to the PI3/PI4-kinase family., similarity:Contains 1 PI3K/PI4K domain., subunit:Probably forms a complex with AMBRA1 and BECN1 (By similarity) . Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4., tissue specificity:Ubiquitously expressed, with a highest expression in skeletal muscle.

Product Name Alternative

Phosphoinositide-3-kinase, class 3

UniProt

Q8NEB9

Swiss Prot

Q8NEB9

Reactivity

Human; Mouse; Rat; Predicted:Cow:PIG

Immunogen

Synthetic Peptide of PI 3 Kinase Class 3

Target

PI 3 Kinase Class 3

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Buffer

-20°C/1 year

Molecular Weight

100kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

100kD

Fragment

IgG

Subcellular Location

Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (PubMed:14617358) . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity) . .