P300 rabbit pAb
E1A binding protein p300 (EP300) Homo sapiens This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Synonyms
EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300
Gene ID
2033
UniProt
Q09472
Cellular Locus
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human p300.
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IF, WB, IHC, ELISA
Validated Applications
IF,WB,IHC,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
300kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8374-1.pdf
Observed Molecular Weight
300 kD
Subcellular Location
Other Product Names
EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300
Gene ID (Human)
2033
SwissProt (Human)
Q09472
Available Sizes
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