Topo IIIα rabbit pAb
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Product Specifications
Background
Synonyms
TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
Gene ID
7156
UniProt
Q13472
Cellular Locus
Mitochondrion matrix.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from Topo IIIα . at AA range: 350-430
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
115kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8351-1.pdf
Observed Molecular Weight
115 kD
Subcellular Location
Mitochondrion matrix .
Other Product Names
TOP3A; TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
Gene ID (Human)
7156
SwissProt (Human)
Q13472
Available Sizes
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