PSI-6206

PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

Product Specifications

CAS Number

[863329-66-2]

Product Name Alternative

RO 2433; GS-331007

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PSI-6206.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=CN1[C@H]2[C@@](F)(C)[C@H](O)[C@@H](CO)O2)NC1=O

Molecular Formula

C10H13FN2O5

Molecular Weight

260.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48 (17) :5504-8.|[2]Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species. J Biol Chem. 2007 Oct 12;282 (41) :29|[3]Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74 (17) :6819-24.