PSI-6206
Product Specifications
UNSPSC Description
PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Target Antigen
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/PSI-6206.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C=CN1[C@H]2[C@@](F)(C)[C@H](O)[C@@H](CO)O2)NC1=O
Molecular Weight
260.221
References & Citations
[1]Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48(17):5504-8.|[2]Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
 J Biol Chem. 2007 Oct 12;282(41):29|[3]Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74(17):6819-24.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15236/PSI-6206-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15236/PSI-6206-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
863329-66-2
Available Sizes
Curated Selection
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