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N-CoR rabbit pAb

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20. [provided by RefSeq, Jun 2010],

Product Specifications

Background

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

UniProt

O75376

Swiss Prot

O75376

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human NCoR1. AA range:51-100

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

270kD

Storage Conditions

-20°C/1 year

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES8074-1.pdf

Observed Molecular Weight

270kD

Fragment

IgG

Subcellular Location

Nucleus .

Other Product Names

NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1

Gene ID (Human)

9611

Available Sizes

Curated Selection

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