Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TTA-P2

TTA-P2 (T-Type calcium channel inhibitor) is a selective, orally active, and BBB-penetrant T-type calcium channel blocker (IC50 = 22 nM) . TTA-P2 reduces mechanical hypersensitivity and alleviates acute as well as chronic pain. TTA-P2 significantly reduces firing rates in temporal lobe epilepsy (TLE) neurons to control levels and suppresses synaptically evoked burst firing. TTA-P2 can be studied in research for neurological diseases such as tremor and absence epilepsy[1][2][3][4][5].

Product Specifications

CAS Number

1072018-68-8

Product Name Alternative

T-Type calcium channel inhibitor

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tta-p2.html

Purity

99.58

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)(OCC1)C[C@H]1CN2CCC(F)(CC2)CNC(C3=CC(Cl)=CC(Cl)=C3)=O

Molecular Formula

C21H29Cl2FN2O2

Molecular Weight

431.37

References & Citations

[1]Huilin Liu, et al., Inhibition of T-Type Calcium Channels With TTA-P2 Reduces Chronic Neuropathic Pain Following Spinal Cord Injury in Rats, The Journal of Pain, Volume 24, Issue 9, 2023, Pages 1681-1695, ISSN 1526-5900.|[2]WonJoo Choe, et al., TTA-P2 Is a Potent and Selective Blocker of T-Type Calcium Channels in Rat Sensory Neurons and a Novel Antinociceptive Agent, Molecular Pharmacology, Volume 80, Issue 5, 2011, Pages 900-910, ISSN 0026-895X.|[3]Dreyfus, F. M., et al., (2010) . Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I (T) window. The Journal of neuroscience : the official journal of the Society for Neuroscience, 30 (1), 99-109.|[4]Nigam, A., et al., (2019) . Inhibition of T-Type calcium channels in mEC layer II stellate neurons reduces neuronal hyperexcitability associated with epilepsy. Epilepsy research, 154, 132-138.|[5]Shipe, W. D., et al., (2008) . Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist. Journal of medicinal chemistry, 51 (13), 3692-3695.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

T-type calcium channel

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Catenin, beta (CTNNB1) (CTNNB1/2030R), CF568 conjugate, 0.1mg/mL
BNC682030-500 1x 500 µL

Catenin, beta (CTNNB1) (CTNNB1/2030R), CF568 conjugate, 0.1mg/mL

Sign In for Pricing
View Details
EFHD1 Mouse Monoclonal Antibody [Clone ID: OTI1C12]
CF812750 100 µg

EFHD1 Mouse Monoclonal Antibody [Clone ID: OTI1C12]

Sign In for Pricing
View Details
Aurkaip1 Mouse Gene Knockout Kit (CRISPR)
KN501871 1 Kit

Aurkaip1 Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
CD61 (ITGB3) Rabbit Polyclonal Antibody
TA364494 100 µL

CD61 (ITGB3) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
QuadCount™ Automated Cell Counter, 230V
E7500-E 1 Each

QuadCount™ Automated Cell Counter, 230V

Sign In for Pricing
View Details
1,2,4-Triaminobenzene Dihydrochloride
TRC-T895865-50MG 50 mg

1,2,4-Triaminobenzene Dihydrochloride

Sign In for Pricing
View Details