Rosmarinic acid

Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively.

Product Specifications

CAS Number

[20283-92-5]

Product Name Alternative

Labiatenic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; COMT; Endogenous Metabolite; Monoamine Oxidase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Rosmarinic-acid.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([C@H](OC(/C=C/C1=CC(O)=C(O)C=C1)=O)CC2=CC(O)=C(O)C=C2)=O

Molecular Formula

C18H16O8

Molecular Weight

360.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Andrade JM, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.|[2]Fernando PM, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul) . 2016 Jan;24 (1) :75-84.|[3]Jin BR, et al. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS) -induced mice via dual inhibition of NF-κB and STAT3 activation. Sci Rep. 2017 Apr 6;7:46252.