Neuralized-1 rabbit pAb

NEURL1B (neuralized homolog 1B), also known as neur2 or NEURL3, is a 555 amino acid protein that functions as an E3 ubiquitin-protein ligase. Involved in protein ubiquitination, NEURL1B contains two NHR (neuralized homology repeat) domains and one RING-type zinc finger. NEURL4 (neuralized homolog 4 (Drosophila)), also known as neuralized-like protein 4, is a 1, 562 amino acid protein that is highly expressed in a wide variety of tissues. Containing six NHR (neuralized homology repeat) domains, NEURL4 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17p13. 1.

Product Specifications

Background

NEURL1B (neuralized homolog 1B), also known as neur2 or NEURL3, is a 555 amino acid protein that functions as an E3 ubiquitin-protein ligase. Involved in protein ubiquitination, NEURL1B contains two NHR (neuralized homology repeat) domains and one RING-type zinc finger. NEURL4 (neuralized homolog 4 (Drosophila) ), also known as neuralized-like protein 4, is a 1,562 amino acid protein that is highly expressed in a wide variety of tissues. Containing six NHR (neuralized homology repeat) domains, NEURL4 exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 17p13.1.

UniProt

O76050

Swiss Prot

O76050

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human NEURL1. AA range:219-268

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

62kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

62kD

Fragment

IgG

Subcellular Location

Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) . Colocalized with JAG1 at the cell surface. .