ERI1 rabbit pAb

Cofactor: Binds 2 magnesium ions per subunit. enzyme regulation: Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity. function: RNA exonuclease that binds to the 3'-end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for 5. 8S rRNA 3'-end processing. sequence Caution: Translated as Leu. similarity: Contains 1 exonuclease domain. similarity: Contains 1 SAP domain. subunit: Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. Requires the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Also binds to 5. 8s ribosomal RNA.