SIRT5 Human Recombinant

<strong>SIRT5 Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2017236_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 60.6 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Mitochondrial Regulatory Protein SIR2 Homolog 5, NAD-dependent Deacetylase 5, NAD-dependent Protein Deacylase Sirtuin-5, Silent Information Regulator 5, SIR2L5, SIR2-like Protein 5, Sirtuin 5_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Wang F, Wang K, Xu W, Zhao S, Ye D, Wang Y, Xu Y, Zhou L, Chu Y, Zhang C, Qin X, Yang P, Yu H. SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice Cell Rep. 2017 Jun 13;19(11):2331-2344._x000D_ 2: Zhou B, Yang Y, Pang X, Shi J, Jiang T, Zheng X. Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer Biomed Pharmacother. 2023 Sep;165:115071._x000D_ 3: Kumar S, Lombard DB. Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein Methods Mol Biol. 2016;1436:241-57._x000D_ 4: Kalbas D, Liebscher S, Nowak T, Meleshin M, Pannek M, Popp C, Alhalabi Z, Bordusa F, Sippl W, Steegborn C, Schutkowski M. Potent and Selective Inhibitors of Human Sirtuin 5 J Med Chem. 2018 Mar 22;61(6):2460-2471._x000D_ 5: Mahlknecht U, Ho AD, Letzel S, Voelter-Mahlknecht S. Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization Cytogenet Genome Res. 2006;112(3-4):208-12._x000D_ 6: Bian M, Li S, Zhou H, Bi L, Shen Y, Tingjin C, Yu X, Huang Y, Xu Q. ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells PLoS Negl Trop Dis. 2023 Nov 10;17(11):e0011727._x000D_ 7: Liu S, Ji S, Yu ZJ, Wang HL, Cheng X, Li WJ, Jing L, Yu Y, Chen Q, Yang LL, Li GB, Wu Y. Structure-based discovery of new selective small-molecule sirtuin 5 inhibitors Chem Biol Drug Des. 2018 Jan;91(1):257-268._x000D_ 8: Zhang Y, Bharathi SS, Rardin MJ, Uppala R, Verdin E, Gibson BW, Goetzman ES. SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase PLoS One. 2015 Mar 26;10(3):e0122297._x000D_ 9: Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES. Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain J Biol Chem. 2017 Jun 16;292(24):10239-10249._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/27577743">10: Liang F, Wang X, Ow SH, Chen W, Ong WC. Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells Neurotox Res. 2017 Jan;31(1):63-76. </a>_x000D_ _x000D_ <strong>Products Related to SIRT5 Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>