MYPT3 rabbit pAb
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016],
Product Specifications
Background
Synonyms
PPP1R16A; MYPT3; Protein phosphatase 1 regulatory subunit 16A; Myosin phosphatase-targeting subunit 3
Gene ID
84988
UniProt
Q96I34
Cellular Locus
Cell membrane ; Lipid-anchor.
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human PPP1R16A. AA range:362-411
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA, IHC
Validated Applications
WB,IF,ELISA,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200
Molecular Weight
60kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7793-1.pdf
Observed Molecular Weight
60 kD
Subcellular Location
Cell membrane ; Lipid-anchor .
Other Product Names
PPP1R16A; MYPT3; Protein phosphatase 1 regulatory subunit 16A; Myosin phosphatase-targeting subunit 3
Gene ID (Human)
84988
SwissProt (Human)
Q96I34
Available Sizes
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