COL25A1 rabbit pAb
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
Product Specifications
Background
Synonyms
COL25A1; Collagen alpha-1(XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P
Gene ID
84570
UniProt
Q9BXS0
Cellular Locus
Membrane ; Single-pass type II membrane protein. After proteolytic cleavage, CLAC is secreted.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Molecular Weight
64kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7762-1.pdf
Observed Molecular Weight
64 kD
Subcellular Location
Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
Other Product Names
COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P
Gene ID (Human)
84570
SwissProt (Human)
Q9BXS0
Available Sizes
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