Gallic acid (hydrate)

Gallic acid (3,4,5-Trihydroxybenzoic acid) hydrate is a natural polyhydroxyphenolic compound and an free radical scavenger to inhibit cyclooxygenase-2 (COX-2) [1]. Gallic acid hydrate has various activities, such as antimicrobial, antioxidant, antimicrobial, anti-inflammatory, and anticance activities[2].

Product Specifications

CAS Number

[5995-86-8]

Product Name Alternative

3,4,5-Trihydroxybenzoic acid (hydrate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; COX; Endogenous Metabolite; Ferroptosis; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gallic-acid-hydrate.html

Purity

99.99

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC(O)=C(O)C(O)=C1.O

Molecular Formula

C7H8O6

Molecular Weight

188.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Felipe Hugo Alencar Fernandes, et al. Gallic Acid: Review of the Methods of Determination and Quantification. Crit Rev Anal Chem|[2]Amaravani M, et al. COX-2 structural analysis and docking studies with gallic acid structural analogues. Springerplus. 2012 Dec;1 (1) :58.|[3]Bak EJ, et al. Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice. Scand J Clin Lab Invest. 2013 Dec;73 (8) :607-14.|[4]Cheng Y, et al. Plant Natural Products Calycosin and Gallic Acid Synergistically Attenuate Neutrophil Infiltration and Subsequent Injury in Isoproterenol-Induced Myocardial Infarction: A Possible Role for Leukotriene B4 12-Hydroxydehydrogenase? Oxid Med Cell Longev. 2015;2015:434052.