Cubilin rabbit pAb

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

O60494

Swiss Prot

O60494

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from the N-terminal region of human Cubilin.

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

400kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

400kD

Fragment

IgG

Subcellular Location

Apical cell membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Membrane, coated pit . Endosome . Lysosome membrane ; Peripheral membrane protein . Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (PubMed:29402915, PubMed:30523278) . Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (By similarity) . .

Other Product Names

CUBN; IFCR; Cubilin; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor