TNF-IP 8L2 rabbit pAb

Domain: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. subunit: May interact with CASP8; however, such result is unclear since PubMed: 19079267 could not reproduce the interaction with CASP8.