TNF-IP 8L2 rabbit pAb
Domain: The central region was initially thought to constitute a DED (death effector) domain. However, 3D-structure data reveal a previously uncharacterized fold that is different from the predicted fold of a DED (death effector) domain. It consists of a large, hydrophobic central cavity that is poised for cofactor binding. function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits jun/ap1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. subunit: May interact with CASP8; however, such result is unclear since PubMed: 19079267 could not reproduce the interaction with CASP8.
Product Specifications
Background
Synonyms
Gene ID
79626
UniProt
Q6P589
Cellular Locus
Cytoplasm,
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human TNFAIP8L2. AA range:11-60
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
20kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES7586-1.pdf
Observed Molecular Weight
20 kD
Subcellular Location
Cytoplasm
Other Product Names
Gene ID (Human)
79626
SwissProt (Human)
Q6P589
Available Sizes
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